Christina Applegate spoke candidly about her multiple sclerosis diagnosis in a recent podcast episode.

The Dead to Me star initially announced her MS diagnosis in 2021, and she has since opened up about how she discovered she had the ailment, which affects both the brain and the spinal cord.

Applegate’s earliest symptoms were as basic as “tingling on her toes,” and within a few months, she was being transported to a wheelchair as she struggled to walk.

In the years since her diagnosis, Applegate has had to cope with the consequences of health concerns in practically every part of her life.

She went into further depth about the kind of scenarios she’s encountered while celebrating the first anniversary of her MesSy podcast when a listener wrote in to share their own experiences.

The listener admitted to ‘throwing up and having diarrhea every single ‘day’—symptoms Applegate said she is quite acquainted with, despite doctors’ claims that they are unconnected to her MS.

The actor responded, “This is really important because for three years, since I was diagnosed, I’ve been in the hospital upwards of 30 times from throwing up and diarrhea and pain that is unimaginable.”

Applegate went on to add that physicians had performed “every test known to man” on her, including putting “so much radiation” in her body, conducting CT scans, and “everything else.”

She went on, “Now, maybe this isn’t what’s going on, but I’m just going to tell you this: Talk to your doctor about your motility difficulties, okay?

Because one of the effects of MS is that it slows down our organs—not entirely, but to a certain extent.”

Not afraid to be explicit, Applegate continued, “To be completely honest, if I have to defecate, I puke. And when I puke, I feel the anguish, and then everything happens.”

She referred to the reaction as the ‘fight club,’ saying, “So, there’s this really nasty dispute.” It’s like everyone is fighting with each other.”

Applegate has endeavored to have a ‘huge talk’ with her medical team regarding the symptoms she has had, which she has attempted to support by undergoing a recent colonoscopy.

“There must be a correlation here,” she informed me.

Symptoms of MS include numbness, weakness, difficulty walking, and visual problems.